diff --git a/pre_commit/clientlib.py b/pre_commit/clientlib.py
index 9f41bf4b..78d0ec44 100644
--- a/pre_commit/clientlib.py
+++ b/pre_commit/clientlib.py
@@ -110,6 +110,7 @@ MANIFEST_HOOK_DICT = cfgv.Map(
 
     cfgv.Optional('files', check_string_regex, ''),
     cfgv.Optional('exclude', check_string_regex, '^$'),
+    cfgv.Optional('exclude_file_path', check_string_regex, '^$'),
     cfgv.Optional('types', cfgv.check_array(check_type_tag), ['file']),
     cfgv.Optional('types_or', cfgv.check_array(check_type_tag), []),
     cfgv.Optional('exclude_types', cfgv.check_array(check_type_tag), []),
@@ -357,6 +358,7 @@ CONFIG_SCHEMA = cfgv.Map(
     StagesMigration('default_stages', STAGES),
     cfgv.Optional('files', check_string_regex, ''),
     cfgv.Optional('exclude', check_string_regex, '^$'),
+    cfgv.Optional('exclude_file_path', check_string_regex, '^$'),
     cfgv.Optional('fail_fast', cfgv.check_bool, False),
     cfgv.Optional(
         'minimum_pre_commit_version',
diff --git a/pre_commit/commands/run.py b/pre_commit/commands/run.py
index 076f16d8..621ff6a3 100644
--- a/pre_commit/commands/run.py
+++ b/pre_commit/commands/run.py
@@ -63,6 +63,7 @@ def filter_by_include_exclude(
         exclude: str,
 ) -> Generator[str, None, None]:
     include_re, exclude_re = re.compile(include), re.compile(exclude)
+
     return (
         filename for filename in names
         if include_re.search(filename)
@@ -98,11 +99,23 @@ class Classifier:
                 yield filename
 
     def filenames_for_hook(self, hook: Hook) -> Generator[str, None, None]:
+        exclude = hook.exclude or '$^'
+        file_exclude = ''
+        if hook.exclude_file_path is not None:
+            if os.path.isfile(hook.exclude_file_path):
+                with open(hook.exclude_file_path) as exclude_file:
+                    file_exclude = '|'.join(
+                        line.strip() for line in exclude_file.readlines()
+                    ) or '$^'
+
+        if file_exclude:
+            exclude = f'{exclude}|{file_exclude}'
+
         return self.by_types(
             filter_by_include_exclude(
                 self.filenames,
                 hook.files,
-                hook.exclude,
+                exclude,
             ),
             hook.types,
             hook.types_or,
@@ -115,6 +128,7 @@ class Classifier:
             filenames: Iterable[str],
             include: str,
             exclude: str,
+            exclude_file_path: str,
     ) -> Classifier:
         # on windows we normalize all filenames to use forward slashes
         # this makes it easier to filter using the `files:` regex
@@ -122,6 +136,15 @@ class Classifier:
         # see #1173
         if os.altsep == '/' and os.sep == '\\':
             filenames = (f.replace(os.sep, os.altsep) for f in filenames)
+        file_exclude = ''
+        if exclude_file_path is not None:
+            if os.path.isfile(exclude_file_path):
+                with open(exclude_file_path) as exclude_file:
+                    file_exclude = '|'.join(
+                        line.strip() for line in exclude_file.readlines()
+                    ) or '$^'
+        if file_exclude:
+            exclude = f'{exclude}|{file_exclude}'
         filenames = filter_by_include_exclude(filenames, include, exclude)
         return Classifier(filenames)
 
@@ -288,7 +311,7 @@ def _run_hooks(
     """Actually run the hooks."""
     cols = _compute_cols(hooks)
     classifier = Classifier.from_config(
-        _all_filenames(args), config['files'], config['exclude'],
+        _all_filenames(args), config['files'], config['exclude'], config['exclude_file_path'],
     )
     retval = 0
     prior_diff = _get_diff()
diff --git a/pre_commit/hook.py b/pre_commit/hook.py
index 309cd5be..38143439 100644
--- a/pre_commit/hook.py
+++ b/pre_commit/hook.py
@@ -20,6 +20,7 @@ class Hook(NamedTuple):
     alias: str
     files: str
     exclude: str
+    exclude_file_path: str
     types: Sequence[str]
     types_or: Sequence[str]
     exclude_types: Sequence[str]
diff --git a/pre_commit/meta_hooks/check_hooks_apply.py b/pre_commit/meta_hooks/check_hooks_apply.py
index 84c142b4..52683196 100644
--- a/pre_commit/meta_hooks/check_hooks_apply.py
+++ b/pre_commit/meta_hooks/check_hooks_apply.py
@@ -1,6 +1,7 @@
 from __future__ import annotations
 
 import argparse
+import os
 from collections.abc import Sequence
 
 import pre_commit.constants as C
@@ -13,6 +14,12 @@ from pre_commit.store import Store
 
 def check_all_hooks_match_files(config_file: str) -> int:
     config = load_config(config_file)
+    exclude_file_path = config['exclude_file_path']
+    if exclude_file_path is not None:
+        if os.path.isfile(exclude_file_path):
+            with open(exclude_file_path, 'r') as f:
+                config['exclude'] = f.read().splitlines()
+
     classifier = Classifier.from_config(
         git.get_all_files(), config['files'], config['exclude'],
     )